In his work, Sousa uses animation and themes commonly found in mythology and fairy tales to examine archetypes of human nature, and the inner struggles between our intellects and our unconscious drives. Rather than following conventional narratives, he approaches filmmaking from a painter’s perspective. He focuses on states of mind, evoking the fragility of fleeting moments, memories and perceptions.
In 2008 he was the recipient of a production grant from the Creative Capital Foundation for the film Feral, which went on to win numerous awards at film festivals around the world, and an Academy Awards nomination in 2013.In addition to his independent projects, Sousa has worked as a director and animator with Cartoon Network, Olive Jar Studios, Global Mechanic, and Duck. He is a founding member of Handcrankedfilm, a film makers' collective, along with Jeff Sias, Bryan Papciak, and Jake Mahaffy.